Barrier Effect of Polymeric and Metalized Nanofiber for Embolization
Aneurysmal subarachnoid hemorrhage (SAH) is extravasation of blood into the subarachnoid space which kills
people. Traditionally platinum coils have been used to fill the hemorrhage so blood extravasation is prevented. Herein, we
introduced both polymeric and platinum nanofibers which enhanced the performance of the blood extravasation prevention.
Nanofibers were produced via electrospinning and were electroplated with platinum, forming metalized nanofibers. These
fibers were installed inside a fluidic channel and their permeability was tested. We show that these fibers are superior to
commercial platinum coils in reducing permeability. These newly developed nanofibers are expected to reduce the SAH
operation cost with their reduced size and low material cost. Because these fibers are superior to the commercial coil in
reducing permeability, it is expected that lesser amount to be used for the SAH operation for the same prevention effect. As a
result, the operational risk involved with multiple deliveries of platinum coils into SAH would be reduced. The theory
describing the permeability of these nanofibers is proposed and tested.
Index Terms- Metalized Nanofiber, Aneurysm Embolization, Permeability, Packing Density