Paper Title
Design and Fabrication of Stimulated Bioreactors For Neural Stem Cell Engineering (Simbion Project)

Microfluidic bioreactor gives a unique environment for culturing cells with its perfusion flow as a growth stimulant. This microenvironment was made of polydimethylsiloxane (PDMS) that offers a high biocompatibility and low toxicity. This bioreactor was made of polydimethylsiloxane (PDMS). It offers an opportunity to overcome previous limitations and recreate critical elements of in vivo microenvironment in order to investigate cellular responses. A dynamic flow of liquid media is employed to mimic the in vivo ambient. Here, we developed bioreactors that equipped with electrical stimulant for neural cells. This paper investigates the fluid dynamic study specifically the shear rate that generated during the flow. Ultimately, this system enables us to observe the interaction between cell and the stimulant. Keywords- microfluidic bioreactor, growth stimulant, microenvironment, neural cell