Paper Title :Safety of Oral Administration of PMF a Fraction Derived From Camel Urine: Acute Study on Mice
Author :Khorshid Fa, Rabah So, Abuaraki H A, Ali As, 5noor So, Alkabkaby H
Article Citation :Khorshid Fa ,Rabah So ,Abuaraki H A ,Ali As ,5noor So ,Alkabkaby H ,
(2018 ) " Safety of Oral Administration of PMF a Fraction Derived From Camel Urine: Acute Study on Mice " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 52-56,
Volume-6,Issue-1,Special Issue - 1
Abstract : Camels researches have attracted interest of scientists since the beginning of the 20th century. Camel urine, a
natural product, has been used long time ago traditionally in the treatment of many diseases in Arabic countries without
scientifically tested. To exploit the therapeutic potential of various ingredients present in camel urine, evaluation of efficacy
and safety profile is required. In the present study, Biochemical analysis and complete blood picture (CPC) were investigated
after oral administration in mice with PMF (a fraction extracted from camel urine). PMF was administered orally with the
therapeutic dose of (0.75ul), two-times, four-times, and twenty-times of the therapeutic dose. Blood samples were collected
from the orbital sinus of mice after 24 hours post-administration. Complete blood picture, liver function testes (ALT, AST,
ALP, GGT, TBIL and ALB). Kidney function testes (Na, K, Ca, Cl, TP, CREA, URECA, BUN, and PHOS) were measured
and statistically analyzed. The results showed that PMF did not have any nephrototxic or hapatotoxic effects as indicated by
the non-significant changes of values of both kidney and liver functions testes. Histopathology examination of liver and
kidney tissues of mice administrated by PMF indicating that there are no alteration in the tissues architectures and pointed
that PMF is a safe fraction even with high doses or long administration time of the therapeutic dose.
Keywords - Camel urine, drug safety, PM701, PMF
Type : Research paper
Published : Volume-6,Issue-1,Special Issue - 1
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-11089
View Here
Copyright: © Institute of Research and Journals
|
|
| |
|
PDF |
| |
Viewed - 15 |
| |
Published on 2018-04-09 |
|